A new Drosophila collection of Parkinsonism models reveals early synaptic cholinergic projection neuron dysfunction, linking synaptic failure to later dopaminergic decline, highlighting a role for ...

Moreover, the neurochemical pathology of PD extends far beyond the nigrostriatal dopaminergic tract, and involves multiple additional locations and neurotransmitters within the brain and also ...

The use of DAT-SPECT can prove or excludes with high sensitivity nigrostriatal dysfunction in those cases and facilitates early and accurate diagnosis. Furthermore, a normal DAT-SPECT is helpful in ...

Because chemogenetic control relies on DREADD expression levels, understanding and quantifying the temporal dynamics of their expression is crucial for planning long-term experiments in monkeys. In ...

Neurodegenerative disorders such as Parkinson’s (PD) and Huntington’s disease (HD) are characterized by a selective detrimental impact on neurons in a specific brain area. Currently, these diseases ...

Correspondence to Professor Ming-Jang Chiu, Neurology, College of Medicine, National Taiwan University, No. 7, Chung-Shan S. Rd, Taipei 10002, Taiwan; mjchiu{at}ntu.edu.tw Objective α-Synuclein is ...

Background: The pathological features of Parkinson’s disease (PD) include the formation of Lewy bodies composed mainly of aggregated alpha-synuclein (α-Syn) and extensive neurodegeneration. Synaptic ...