Casali's team also started with immunodeficient mice (NSG W41 mutants), injecting human stem cells purified from umbilical cord blood through the animal's left ventricle. After a period of weeks ...

Immune humanized NSG variants, co-engrafted with allogenic or autologous patient-derived xenografts (PDXs) or cell–line derived xenografts, referred to as Onco-Hu mice, offer a platform for such ...

Results show that the team created a new mouse breed, called NSG-Pro, that produces levels of human prolactin similar to those in patients with metastatic estrogen receptor-positive breast cancer.

The Jackson Laboratory imported the strain in 2015 in anticipation of distribution, but has since discontinued production of MISTRG mice. Fortunately for the research community, both the NSG ...

When asked why he thought the MISTRG mice were able to engraft NHP HSCs where NSG mice failed, Dr. Radtke said, “MISTRG mice are genetically modified and specifically optimized to support the ...

Immunoscore based on PD-L1/PD-1 and CD8+ T cells as prognostic marker for stage II/III gastric cancer.

A new study published in Microbiology Spectrum reports the establishment of a liver-humanized NSG-PiZ mouse model that is fully permissive to hepatitis B virus (HBV) infection. In this model, HBV can ...

Peripheral blood T cell subset phenotype analysis in melanoma patients treated with combination nivolumab + ipilimumab compared to ipilimumab alone. Updates on phase1b/2 trial of the indoleamine ...

This new mouse model, called NSG-Pro, supports greatly enhanced growth of implanted ER-positive human breast cancers. Molecular pathway analyses of the tumors revealed that prolactin collaborates ...