JAX, with over 11,000 strains, enables access to cutting-edge, humanized-PBMC-NSG™- mice—one of the most widely used models to study human-to-mouse-xenogeneic GvHD, as well as immune function ...

By 16 weeks post engraftment, approximately 50% of humanized NSG™-SGM3 mice are expected to succumb to anemia, whereas huNOG-EXL viability remains >90%.

NSG-Pro mouse model for uncovering resistance mechanisms and unique vulnerabilities in human luminal breast cancers. Science Advances , 2021; 7 (38) DOI: 10.1126/sciadv.abc8145 Cite This Page : ...

MCW scientists have created mice with a hormone profile that casues growth and metastatic spread of implanted human breast tumores. Published in Science Advances, results show that the team ...

In a recently published study by Zhou and colleagues used NSG™ mice from JAX to test CAR T therapy in TNBCtumor (Zhou et al., 2019). NSG™ Mice Reveal the Effect of CAR T Therapy.

Super immunodeficient mice such as the NOG-EXL and NSG-SGM3 combine severe immunodeficiency with transgenic expression of human myeloid-stimulatory cytokines. These mouse strains support an improved ...

"The NSG-Pro mouse model provides previously inaccessible precision medicine approaches for ER-positive human breast cancers," said Yunguang Sun, MD, PhD, joint lead author of the study and ...

Looking for spontaneous metastasis to the brain, Jennifer Koblinski and her colleagues turned to the NSG mouse. Their nude-to-NSG comparison can be found in PLoS One (11, e0163521; 2016).

A new study published in Microbiology Spectrum reports the establishment of a liver-humanized NSG-PiZ mouse model that is fully permissive to hepatitis B virus (HBV) infection. In this model, HBV can ...

Among the more than 4,000 mouse mutant strains that the Jackson Lab maintains and distributes to the worldwide academic community is a mouse similar to NOG, called NSG.