The study found that the new mRNA vaccine was successful in triggering an immune defense response that helped to reduce TB numbers in infected mice. In addition, the researchers discovered that ...

“And what we could show was that when we transferred Tregs into aged mice receiving cancer therapies, we could even boost their function. It's not only the young thymus that can be receptive to ...

Administration of NS398 substantially reduced these changes in TGRKO mice (Fig. 3d). In situ hybridization showed that COX-2 mRNA was induced ... analysis of heart (H), thymus (T), kidney (K ...

French researchers have used a protein called receptor activator of NF-κB ligand (RANKL) to revive the structure and function of the thymus in old mice. The thymus sits in front of the heart and ...

difficile—at least in mouse models. The messenger RNA (mRNA) in vaccines used to fight COVID-19 involves getting human T cells to create proteins that indirectly interrupt the virus's ability to ...

Now, researchers have developed an mRNA vaccine that protected mice from succumbing to C. diff infections and prevented recurring cases. The results suggest the vaccine could become a flexible ...

difficile infection, offering a promising new prophylactic strategy.” The mRNA-LNP inoculation protected mice from an initial C. difficile infection and prevented recurrences in mice that ...

difficile’s ability to cause disease. In laboratory mice and hamsters, the mRNA vaccine elicited a more robust uptick in a variety of immune cells — including antibodies, immunoglobulins and T ...

Novel TROP2-targeted CAR T cells with high specificity and sustained efficacy for solid tumors in animal models. This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This abstract ...

The mRNA therapeutic successfully combated cancerous cells and tumors in vitro as well as metastases in mice. Each year, several thousand women in Germany die from ovarian cancer. In many cases, the ...

Objectives: Normal commitment of the endoderm of the third pharyngeal pouch (3PP) is essential for the development and differentiation of the thymus. The aim of this ... the relative mRNA expression ...