Scientists have uncovered a crucial pathway that may help preserve thymic function as we age. The findings focus on ...

The University of Texas Health Science Center at San Antonio (UT Health San Antonio) scientists have uncovered a crucial pathway that may help preserve thymic function as we age.

The thymus is a crucial training ground for T-cells, the body's "white knights," where they learn to battle the various diseases they may encounter. Thymic function shrinks to nearly nothing as we age ...

CD4 T helper cells are a type of white blood cell called a lymphocyte that serves an important role in your immune system. These cells help defend the body against infection by directing other "killer ...

Bielschowsky, M., Helyer, B. J., and Howie, J. B., Proc. Univ. Otago Med. Sch., 37, 9 (1959).

Cancer of the thymus gland is rare. Most cancers that start in the thymus gland are called thymomas. There’s also a much rarer form of thymus gland cancer called thymic carcinoma. The thymus gland is ...

Mouse H-2 histocompatibility antigen has been extracted, solubilized, and partly purified from the cells of an A strain spontaneous leukemia carrying TL (thymus-leukemia) antigens. H-2 and TL. 1, 2, 3 ...

Furthermore, a global lack of T cell tolerance to murine and human self antigens is a major driver of autoimmune disease among HIS mice whose T cells develop in a murine thymus. In contrast, the ...

based on mouse Immgen transcript data, Fezf2 shows the highest specificity and restricted expression to brain tissues and mTECs in the thymus, followed by Elf3, which is only reported in mTECs in the ...

Runx proteins (also known as Runt-domain transcription factors) have been studied for a long time as key regulators of cellular differentiation. RUNX2 has been described as essential for osteogenesis, ...

In thymic epithelial cells, the research team upregulated a transcription factor called Forkhead box N1 (FOXN1), which had previously been implicated in age-related thymus shrinkage. Consequently, the ...