Lung macrophages play a pivotal role in diseases like idiopathic pulmonary fibrosis. Two types of macrophages—the white blood ...

Researchers in Japan have successfully generated lung cells similar to alveolar epithelial type 2 (AT2) cells from mouse embryonic fibroblasts without using stem cell technology.

The UCLA advance opens the door to growing other vascularized organ models, including intestines and colons, providing ...

Researchers in Japan have successfully generated lung cells similar to alveolar epithelial type 2 (AT2) cells from mouse ...

The fibroblasts were directly converted into iPULs (induced pulmonary epithelial-like cells)—functionally akin to native AT2 ...

Scientists at The Jackson Laboratory (JAX) have developed mouse models that survive premature death and enable pre-clinical ...

Figure 3 S-LV mouse lung infection is limited by hACE2 availability. (A) Experimental design for in vivo investigation of S-LV dose-response. BALB/c mice (n=3/group) were dosed intranasal with 1E11 GC ...

Pulmonary dysfunction is linked to an imbalance in macrophage M1/M2 populations (Rossaint et al, 2021) and we observed an increase in M1/M2 macrophage ratio in HH + STIA mouse lung samples (Fig. 3B), ...

Funding information This work was supported in part by the NIH grant HL084385. Reprint Address Anne M Manicone, Center for Lung Biology, 815 Mercer Street, Box 358050, Seattle, WA 98115. E-mail ...

Role of the Pulmonary Epithelium and Inflammatory Signals in Acute Lung Injury Anne M Manicone Disclosures Expert Rev Clin Immunol. 2009;5 (1):63-75. 0 ...

Potassium channels play an important role in regulating pulmonary vascular tone, the response to hypoxia, and are inhibited in patients with pulmonary hypertension. 2425 Decreased K + conductance ...