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Background Chronic inflammation and elevated reactive oxygen species are key contributors to hepatocellular carcinoma (HCC) ...
This is a useful study in the role of CHI3L1 in Kupffer cells, the macrophages of the liver, showing that CHI3L1 alters glucose regulation in obesity. Specifically, Chi3l1 protects glucose-dependent ...
Immunofluorescence image of mouse liver 72 hours after acetaminophen administration. TP53INP1 (green) marks a distinct population of cells emerging around necrotic areas. This image highlights the ...
This review provides a detailed examination of experimental mouse models used to study liver fibrosis regression, both in vivo and ex vivo, highlighting their relevance, advantages, and limitations.
Illustration by Haneni Bae CHAMPAIGN, Ill. - A new mouse model mimicking the liver symptoms of myotonic dystrophy type 1 - the most prevalent form of adult-onset muscular dystrophy - provides insight ...
Altered drug metabolism and increased susceptibility to fatty liver disease in a mouse model of myotonic dystrophy. Nature Communications, 2024; 15 (1) DOI: 10.1038/s41467-024-53378-z ...
The paper “Altered drug metabolism and increased susceptibility to fatty liver disease in a mouse model of myotonic dystrophy” is available online. DOI: 10.1038/s41467-024-53378-z ...
This application focus explores how spatial profiling with the MICS (MACSima™ Imaging Cyclic Staining) technology can address this knowledge gap in liver metastases research with same-section ...
Mouse-rat chimeras born from these engineered embryos contained mouse cells in most parts of the body including the livers. The percentage of live mouse liver cells enriched was up to 20.6% from ...
Objective HCV infection affects millions of people worldwide, and many patients develop chronic infection leading to liver cancers. For decades, the lack of a small animal model that can recapitulate ...
In the United States, an estimated 30 to 40% of the population has been diagnosed with non-alcoholic fatty liver disease (NAFLD) alone. Yet liver disease has been difficult to study in animal models.
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