After obtaining an entire elastic lung model, I will run particle deposition studies on a technology called the Next Generation Impactor (NGI) and analyze the deposition of particles from an inhaler.

On the day after the final injection, we killed the mice by CO 2 asphyxiation and obtained spleens, lungs, bone marrow and peritoneal exudate cells from each mouse. We pooled tissues of the same ...

For gene therapy to work well, therapeutic molecules need to be efficiently delivered to the correct locations in the body—a ...

and colleagues used a lung-targeted CRISPR-Cas9 drug delivery strategy to knock down cyclin-dependent kinase 4 (CDK4) in tumors, resulting in synthetic lethality in a KRAS-mutant mouse model of ...

degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models.” Previous studies have shown that cationic lipids are more likely to successfully deliver their conte ...

For this, they used a mouse line that carries ... exciting,” said Gaurav Sahay, a drug delivery scientist at Oregon State University. According to him, the LNPs’ ability to deliver gene-editing ...

Gliptin treatment sped up recovery in several mouse models of lung injury. But these oral drugs do not easily enter the organ; researchers had to use very high doses, which made repurposing ...

and Model Medicines is working on one compound to kill them all. The AI drug discoverer’s oral small molecule was able to reduce SARS-CoV levels in the lungs of infected mice and also ...

When you swallow a pill, only a fraction of the drug ends up where it’s needed. Active compounds diffuse across the intestinal wall and are diluted in rivers of blood, aimlessly drifting with the ...

An experimental drug now in clinical trials as a cancer ... Johns Hopkins Medicine investigators report, based on mouse-model research of the lung-damaging disease. Findings from the study ...

They designed tiny drug-delivering vehicles ... the localized and active delivery of medicine," said Zhang. While the idea of breathing in tiny robots to treat our lungs may have sounded far ...

16, which we initially engineered to enter the central nervous system, also efficiently targeted lung ... using a mouse model of the respiratory disease. They also used the tool to delivery ...