Deciphering the gut biome's, including helminths', influence on human trained immunity will unlock novel immunotherapies harnessing the immune reprogramming potential of their secreted factors and ...

In this application note, explore how scientists can couple a serum-free medium with a xeno-free serum replacement to effectively culture functional monocyte-derived dendritic cells and macrophages.

This was accompanied by heightened secretion of proinflammatory cytokines such as IL (interleukin)-6 and ... differentiated primary human monocyte-derived macrophages (hMDMs) exposed to homogenates of ...

Objective We aimed at investigating the effects of biliary epithelial cell-derived acute phase response protein orosomucoid 2 (ORM2) in shaping monocyte/macrophage response to liver injury. Design ...

Following liver injury, the release of DAMPs or PAMPs activates KCs and monocyte-derived macrophages, which in turn release pro-inflammatory cytokines such as TNF-α and IL-1β. These cytokines ...

To gain insight into its role in arthritis and given that NAMPT is identified as a novel mediator of innate immunity, we addressed the function of monocyte-derived NAMPT in experimental arthritis by ...

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The study 'Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages' led ... of messenger substances, so-called cytokines, that can activate numerous immune ...

The study, "Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages ... of messenger substances, so-called cytokines, that can activate numerous immune ...

In our cohort, two vaccinations were required for the release of significant amounts of cytokines in stimulated cells suggesting the induction of a memory response by the first priming vaccine in ...