Damage to the genetic material of mitochondria—the mitochondrial ... has identified a specialized recycling system, which cells activate when they identify damage to the mtDNA.

"These defense and recycle pathways of the mitochondria are essential in organisms ... the UPRmt and mitophagy defense systems in a worm model (C. elegans) of Alzheimer's disease.

now describe in the scientific journal Science Advances how cells with defective mitochondria activate a special recycling system to eliminate damaged genetic material. Damage to the genetic material ...

Researchers now describe how cells with defective mitochondria activate a special recycling system to eliminate ... using fruit flies (Drosophila) as a model organism. Dr Kakanj showed that ...

Researchers at the Hospital for Sick Children (SickKids) report that mitochondria depend on a newly discovered recycling mechanism. Their research demonstrates mitochondria can recycle a localized ...

By slicing a donated brain into more than seven hundred small cubes and measuring both the number of mitochondria and their ... By training the model on 80 percent of their tissue samples and ...

Surprisingly, we found that manganese was more harmful to the cell’s waste recycling system than to its mitochondria, causing buildup of toxic proteins before mitochondria became dysfunctional.

"If we can find existing drugs or develop new ones that prevent damage to the mitochondria we would have a potential treatment for PD," said Buck faculty Xianmin Zeng, PhD, lead scientist on the ...

Surprisingly, we found that manganese was more harmful to the cell’s waste recycling system than to its mitochondria, causing buildup of toxic proteins before mitochondria became dysfunctional.