Stealth BioTherapeutics Inc. (the "Company" or "Stealth"), a clinical-stage biotechnology company focused on the discovery, development and commercialization of novel therapies for diseases involving ...

An international research team has provided a detailed insight into how the spatial organization of genetic material is established in the cell nucleus of early embryos within the first hours after ...

Mitochondrial homeostasis is crucial for the maintenance of cellular equilibrium. In neurons, which are non-regenerative cells, mitochondrial dysfunction ...

Diabetic nephropathy (DN), characterized by progressive damage to the glomeruli and tubulointerstitial compartments, is ...

When the mechanisms that replicate or repair mitochondrial DNA (mtDNA) fail, it can cause a wide range of syndromes for which there are few to zero existing treatment options. One of the causes of ...

The POLG gene regulates the production of DNA polymerase gamma, an enzyme that copies mitochondrial DNA. Without it, the mitochondria cannot function normally and, as a result, fail to provide the ...

Scientists at Johns Hopkins Medicine say they have discovered how a group of proteins linked to Parkinson's disease and amyotrophic lateral sclerosis act as "guardians" of mitochondria, small ...

Damage to the genetic material of mitochondria – the mitochondrial DNA or mtDNA for short – can lead to diseases such as Parkinson’s, Alzheimer’s, amyotrophic lateral sclerosis (ALS), cardiovascular ...

While previous research on these remains has focused on their mitochondrial DNA, which is passed down from mothers to their children, no one had yet looked at the nuclear DNA of each individual. This ...