In the second, chromosomes are the source of microtubule assembly and organization 4. A centrosome-independent pathway exists in some organisms and types of cell, including in female germ-cell ...

GTP hydrolysis is not required for microtubule assembly per se but is necessary for switching between catastrophe and rescue.

Meiotic errors in oocytes cause egg aneuploidy. This study shows that kinetochores employ MPS1 kinase to promote timely ...

Our goal was to understand the process of microtubule assembly and disassembly." Says Wang, "Our current work actually revealed the structures of different tubulin assemblies at the very ends of ...

Microtubule lattice Associates with microtubules and promote assembly and stabilization. MAP4 rabbit polyclonal antibody Acetylation detection: Immunocytochemistry of formaldehyde-fixed HeLa cells ...

Researchers led by Dr. Jens Lüders at IRB Barcelona have discovered a key role played by the ch-TOG protein in the initiation of microtubule assembly during the interphase stage of the cell cycle ...

Branching microtubule nucleation depends on several pieces of molecular machinery. One piece, called the gamma-tubulin ring complex (γ-TuRC), initiates the assembly of tubulin molecules into ...

Mutation of Lis1, a key dynein regulator, can lead to the rare mental developmental disorder lissencephaly, or “smooth brain, ...

A study from researchers at IRB Barcelona and CNIO has unveiled the role of CDK5RAP2 in activating the γ-tubulin ring complex (γTuRC), a vital component for microtubule formation in cells. By using ...

"This is the first time anyone has been able to get an atomic-resolution structure of any microtubule-associated protein assembled on polymerized microtubules," Polenova says. "With magic-angle ...

Microtubules are formed by the polymerization of dimers of α-tubulin and β-tubulin, which dynamically assemble into a polarized structure that serves as a track for microtubule motor proteins ...

This is critical because both the stable and dynamic regions of the microtubule must be present in the brain for successful cognitive function, according to Liang Oscar Qiang, PhD, the study’s lead ...