This study provides valuable findings on the role of site-specific DNA methylation changes during spermatogenesis and their contribution to paternal epigenetic inheritance. The study proposes that ...

The tandem mtZFNs allow efficient packaging into a single AAV, reducing the mtDNA mutation load in cardiac and skeletal muscle tissues in a mouse model. This approach showed significant molecular ...

For example, in March 2023, Illumina Inc., a U.S.-based biotechnology company, introduced Illumina Complete Long Read Technology, which facilitates both long-read and short-read sequencing on a ...

and the KAPA HyperPrep kit (Roche #KK8504) following manufacturer’s protocols and using Illumina TruSeq dual indexes. Library size was checked by TapeStation 4200 (Agilent) and quality control (QC) ...

Whole blood samples from these patients were analyzed using the Infinium MethylationEPIC v2.0 kit ... for DNA methylation analyses were conducted, consisting of the discovery phase using Infinium ...

Objectives This study aims to elucidate the microbial signatures associated with autoimmune diseases, particularly systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), compared ...

In the genome-wide methylation ... Kit (D5002, Zymo Research, United States) based on the manufacturer’s standard protocol. Bisulfite-converted DNA was whole-genome amplified and enzymatically ...

We describe here a role for DNA methylation and MBD2 in the silencing of the human fetal γ-globin gene. The γ-globin gene is reactivated upon treatment with the DNA methyltransferase inhibitor ...