Polymerase-1 Expression Melanocortin-1 receptor (MC1R) plays a critical role in human pigmentation and DNA repair mechanisms. MC1R-targeting agents are being investigated in clinical trials in ...

Genomic tests (diagnostic or prognostic) are becoming increasingly popular and mainstream, but many are plagued by 3 potential deficiencies including: Identification of disease for which nothing ...

Dersimelagon is a new, orally administered, selective melanocortin 1 receptor agonist that increases levels of skin eumelanin. We conducted a randomized, placebo-controlled, phase 2 trial to ...

a potent melanocortin-1 receptor (MC1R) agonist, in ulcerative colitis (UC). The study is evaluating the safety, tolerability, efficacy, pharmacokinetics, and biomarkers of orally administered ...

a selective melanocortin-1 receptor (MC1R) agonist, in patients with active ulcerative colitis (UC). This study was designed to assess the safety, tolerability, and effectiveness of PL8177 when ...

"We are excited to advance oral PL8177, a potent, selective melanocortin-1 receptor agonist, into a Phase 2 clinical trial in patients with UC, an inflammatory bowel disease that affects an ...

Orally administered PL8177 is designed to target melanocortin-1 receptors on the surface of cells lining the colon. In a Phase 1 clinical trial, the oral version of PL8177 was shown to effectively ...

Orally administered PL8177 targets melanocortin-1 receptors on the luminal surface of colon epithelial cells. In a Phase 1 clinical study, the oral formulation successfully demonstrated sustained ...

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