Recent advances in cancer research have underscored the critical role of myeloid cells in shaping tumor microenvironments ...

Arginase 1, inducible nitric oxide synthase, reactive oxygen species and peroxynitrite are thought to have a role in MDSC-mediated T-cell suppression. Agents that may be effective for targeting ...

Here, we studied whether exosomal miR transfer contributes to CLL-cell-mediated MDSC induction and whether vitamin D holds any regulatory role in this process. Understanding this interplay is of ...

Previously, researchers in another group had found a way to break the protective layer around tumours in mice by using antibodies that attach to the MDSC cell surface, marking it for destruction ...

Some studies have shown MDSC concentrations to be associated with overall survival and response to therapy in renal cell carcinoma. MDSCs comprise a heterogenous population that are yet to be fully ...

Background: A suppression of cell mediated immunity and malnutrition are commonly seen in patients with advanced cancer and it has been reported that chronic inflammation plays a key role in induction ...

A type of aggressive, treatment-resistant brain tumor has a distinct population of immune cells that support its growth, according to new research led by investigators at the Johns Hopkins Kimmel ...

More information: Livingstone Fultang et al, MDSC targeting with Gemtuzumab ozogamicin restores T cell immunity and immunotherapy against cancers, EBioMedicine (2019). DOI: 10.1016/j.ebiom.2019.08.025 ...