N=4-9 eyes per group. (G) Representative hematoxylin and eosin stained retinal sections from rod photoreceptor-specific Gls conditional knockout (cKO) mice compared to wild-type (WT) mice at P14, P21 ...

Dsc2 KO and knock-in (KI) mouse models were generated using CRISPR/Cas9 technology on a C57BL/6J genetic background. Dsc2 KO mice were generated by deleting exon 4. KI mice were created by inserting ...

Department of Neurosurgery, The Institute Translational Medicine, Shenzhen Second People’s Hospital/The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China ...

This important study provides solid evidence that glucosylceramide synthase (GlcT), a rate-limiting enzyme for glycosphingolipid (GSL) production, plays a role in the differentiation of intestinal ...

Here, the well-known Piezo1 was studied through a conditional knockout mouse model as a major mediator for ultrasound neuromodulation ex vivo and in vivo. We showed that Piezo1 knockout (P1KO) in the ...

The prostate-specific Pten conditional knockout mouse model closely imitates human PCa initiation and progression. To better understand how age impacts PCa in an experimental model, we have generated ...

Both D1R and D2R knock out (KO) mice of the major dopamine receptors show significant motor impairments. However, there are some discrepant reports, which may be due to the differences in genetic ...