Researchers led by Université de Montréal pathology and cell-biology professor Marc Therrien have identified major structural ...

Drugmakers are turning to biomarkers, like folate receptor alpha, and even cell therapies to tackle this deadly cancer in new ...

PRESS RELEASE AB SCIENCE ANNOUNCES THE SETTLEMENT DELIVERY OF ITS LATEST CAPITAL INCREASE FOR €1.8 MILLION Paris, May 23, 2025, 8am CET AB Science S.A. (the “Company” or “AB Science”, Euronext – ...

Arcus Biosciences Inc. has identified mast/stem cell growth factor receptor Kit (KIT; c-Kit; CD117) inhibitors reported to be useful for the treatment of cancer, allergy, autoimmune, inflammatory, ...

Recludix Pharma, a leader in the discovery of inhibitors for challenging targets in inflammatory disease, today announced a ...

Depending on where the mast cells have accumulated ... In the last few years, tyrosine kinase inhibitors (called KIT inhibitors) have really transformed treatment of advanced systemic mastocytosis ...

underscoring the importance of treating patients early in the ISM disease course -- -- BLU-808 healthy volunteer trial results demonstrate wide therapeutic window for modulating mast cell activity ...

Human stroke patient dura and blood was sampled to assess mast cell activity and to identify potential ligands for Mrgprb2 activation. Lastly, we used osthole, a Mrgprb2 inhibitor, as a post-MCAO ...

She added, "mast cell activation, or mast cell hyperactivity ... Symptomatic response to MC activation inhibitors can also be used but isn't required as it is in the other definition.

We wondered whether curcumin might also potentially inhibit this particular enzyme. And we found that it did. It inhibited the enzyme's catalytic activity. Furthermore, we found that mast cells ...

Because of this opposition to multiple activation pathways, AK006 has the potential to inhibit multiple modes of mast cell activation and has demonstrated preclinical inhibition of mast cell ...

“The allergen would normally activate the mast cell. But at the same time the allergen binds, the antibody on the nanoparticle also engages the inhibitor Siglec-6 receptor. Given these two ...