When people think of DNA, they usually think of genes, the parts that code for proteins and drive inherited traits. But there ...

DNA or deoxyribonucleic acid is the basic hereditary material present in all the cells of an organism and basically provides a blue print for the cell’s functions, growth, reproduction and death ...

A favoured model was that the sequence was read as hydrogen bonds formed between the protein and bases in the major groove of the DNA helix.

The DNA double helix has two grooves, a major and a minor one, that wind around the central axis of the molecule, and reading is achieved using hydrogen bonds that form between protein side chains ...

Major‐groove DNA contacts are contributed by the NTD of CSL through residues Arg234, Lys368, and Gln226, which combine to specify the sequence 5′‐G (8)GGA‐3′ in the second half of the DNA‐binding site ...

Specificity of Minor-Groove and Major-Groove Interactions in a Homeodomain-DNA Complex ...

DNA major-minor groove binding specificity of daunorubicin: anthramycin-modified and T-4 bacteriophage DNA studies Shau Fong Yen , Wayne Germon , and W. David Wilson ...

The DNA is kinked at the two recognition helix contact sites, and the DNA region between the kinks is straight. Among the major groove protein‐bound DNAs, this ‘kink–straight–kink’ bend contrasts with ...

Abstract Developing minor groove-binding drugs to selectively inhibit transcription factor (TF)/DNA interactions and accompanying gene expression is a current goal in drug development studies.

The interduplex contacts are head-to-tail base pair stacking and backbone/major-groove interactions that are commonly found in B-DNA crystals (27). The three duplexes of ACCGAATTCGGT are illustrated ...