DNA Grooves. As the DNA strands are twisted they have distinct grooves. DNA has two kinds of grooves that play important roles in its functioning. Major and minor grooves help in formation of ...

Solvent interactions in E-DNA. The deep major groove and shallow minor groove, along with the relatively noninclined base pairs result in a more exposed surface for E-DNA.

DNA-binding proteins have the daunting task of finding their binding sites among the 3 billion base pairs of the human genome. The shape of DNA, and not just its sequence, may offer proteins much ...

This DNA tetrahedron is the smallest 3D nanostructure made by DNA self-assembly. Comparison between the 3D density map and structural models of the two expected diastereomers. (a,b) Space-filling ...

When we tried targeting duplex DNA with homopyrimidine PNA, to our surprise the PNA did not bind in the DNA’s major groove as planned. Instead one PNA strand invaded the helix, ...

Such an evolutionary order makes sense, Porter says, because the helix-turn-helix binds only to the major groove of DNA, whereas the winged helix binds to both the major groove and the minor groove.

The first is the direction of the helix. The most common form of DNA (the variety that's found in almost all known life) is called B-DNA, and it twists to the right. This can be very difficult to ...

New study finds that DNA molecules directly interact with one another in a way that's dependent on the sequence of the DNA and epigenetic factors. ... relocating spermine from major grooves to ...

Structurally, the 147-bp DNA fragment can be divided to two halves by the dyad at position 74. Each half is consisted of six minor-groove bending sites (GBS) (at superhelical locations (SHL) -6.5 to ...