The E-DNA surface is highly accessible to solvent, with waters in the major groove sitting on exposed faces of the stacked nucleotides.

The bases zip together with standard Watson-Crick bonding. When we tried targeting duplex DNA with homopyrimidine PNA, to our surprise the PNA did not bind in the DNA’s major groove as planned.

A triple-helix DNA structure can form when certain nucleobases – pyrimidine or purine – occupy the major grooves in conventional B-DNA. This can happen naturally or as part of intentional ...

The first is the direction of the helix. The most common form of DNA (the variety that's found in almost all known life) is called B-DNA, and it twists to the right. This can be very difficult to ...

DNA or deoxyribonucleic acid is the basic hereditary material present in all the cells of an organism and basically provides a blue print for the cell’s functions, growth, reproduction and death ...

Such an evolutionary order makes sense, Porter says, because the helix-turn-helix binds only to the major groove of DNA, whereas the winged helix binds to both the major groove and the minor ...

This DNA tetrahedron is the smallest 3D nanostructure made by DNA self-assembly. Comparison between the 3D density map and structural models of the two expected diastereomers. (a,b) Space-filling ...

Methyl groups of thymine act as a steric block, relocating spermine from major grooves to interhelical regions, thereby increasing DNA–DNA attraction.” ...

Both ZFN and TALENs are modular proteins that interact with the major groove of the double helix structure of DNA in order to recognize specific base pairs.

Maynooth University has been awarded €4m in EU funding for the development of a DNA-based computing and information storage system.

DNA comprises two polynucleotide strands, which form a double helix. B-DNA is the “Watson-Crick” form of DNA, which is in the form of a right-handed helix with a helical repeat (pitch) of ~3.6nm, with ...