Age affects every type of body tissue, including skin, muscles, bone, and more. Learn about the specific effects of aging on ...

This study presents an important finding on the role of GATA4 in aging and OA-associated cartilage pathology. The evidence supporting the conclusions is compelling, with rigorous in vitro and in vivo ...

Researchers conducted RNA sequencing and found the metastases fell into three distinct ecosystem archetypes characterized by enrichment of different immune cells: 1) macrophages and osteoclasts, 2) ...

Bone is a common site for metastasis of solid cancers, but histological and molecular features of bone metastases are not ...

In a new study published in Cell Genomics, researchers use RNA sequencing to characterize bone metastases from eight cancer types. The findings ...

In just 3 years, striking new advances have been made in understanding the molecular mechanisms that govern the crosstalk between osteoblasts/stromal cells and hemopoietic osteoclast precursor ...

We hypothesized that macrophages differentiate into osteoclasts in aneurysmal arteries and that protease byproducts contribute to aneurysm pathophysiology. We performed histological and ...

Osteoclasts arise from the differentiation of macrophages or monocytes, which are types of immune cells. Suppressing osteoclast differentiation can, therefore, serve as a therapeutic strategy to ...

Macrophages undergo plasma membrane fusion and cell multinucleation to form multinucleated giant cells (MGCs) such as osteoclasts in bone, Langhans giant cells (LGCs) as part of granulomas or ...