Joint injury induces rapid and sustained diversification of resident and infiltrating synovial macrophage phenotypes, underpinning osteoarthritis-associated synovitis.

Osteoclasts derive from a myeloid progenitor that gives rise to both the monocyte-macrophage lineage and the osteoclast lineage. A mononuclear pre-osteoclast exists that expresses both TRAP and CTR.

Osteoblast-mediated bone formation, osteoclast-mediated bone resorption and macrophage-regulated inflammatory response play a central role in the process of bone remodeling, which together maintain ...

The enzyme aconitate decarboxylase 1 (Acod1) is known to link the cellular function of monocyte-derived macrophages to their metabolic status. As osteoclasts derive from the monocyte lineage, we ...

This study demonstrated that CAG dose-dependently inhibited osteoclast formation in receptor activator of nuclear factor-κB ligand (RANKL)-stimulated bone marrow macrophage (BMMs). Mechanism studies ...

RAW 264.7 Mouse monocyte/macrophages (TIB-71, ATCC, Manassas, Virginia, USA) 1×10 5 /well were cultured in 24-well plates and stimulated with 100 ng/ml purified glutathione-S-transferase (GST)-RANKL ...

We have observed that it inhibits both interleukin (IL)-1β and tumor necrosis factor (TNF) in vitro, and that it has anti-inflammatory properties and ability to decrease synovial CD68+ macrophages ...

Understanding why newborns, but not adults, can regenerate the heart could lead to treatments that "reprogram" adult ...

An increase in high-fat, high-fructose foods in people's diets has contributed to a dramatic increase in type 2 diabetes.

Solid tumors are difficult to treat due to their heterogeneity and limited blood supply, which restrict the effective ...