Osteoclasts develop from the development of macrophages or monocytes, two types of immune cells. Suppressing osteoclast ...

A study has identified three new genes that regulate osteoclasts and are implicated in Paget disease; however, the clinical utility of these findings remains questionable. Paget disease of bone is ...

A recent study that is yet to be published provided insights into the process of osteoclast differentiation and revealed potential therapeutic targets which can be pursued to develop treatments ...

TREM2 is expressed by tissue macrophages in various parts of the body, including the central nervous system (microglia), the bone (osteoclasts), liver, adipose tissue, skin, gut, and tumor ...

These macrophages activate ATF6, which then enhances the transcription of TNFα by binding to its promoter. This process accelerates osteoclast activity, promoting bone resorption and speeding up ...

A new study in mice shows how the small GTPase Cdc42 influences bone modeling and remodeling—it modulates both the formation and function of osteoclasts, and is involved in the downstream ...

06:00 The blue areas are bone, and the red parts resembling amoebas on the bone's surface are osteoclasts. However, any imbalance causing too many of these macrophages to move to bones results in ...

Patients with systemic sclerosis and calcinosis cutis may have a higher tendency for bone-resorbing cell activity, suggesting ...