Oncolytic adenovirus was engineered for the forced ectopic delivery of peptide-MHC ligand of T cell receptors (TCRs) to ...

Proteins change their conformations as part of their biological functions, for example, when binding another molecule (ligand). Two pathways are conceivable: Either the ligand binds preferentially to ...

The major histocompatibility complex (MHC) is a cluster of genes encoding molecules that are important for lymphocyte activation. MHC molecules bind small fragments of proteins from inside a cell ...

Whole blood was stained with the direct addition of 1 μL of PE-conjugated H-2K(b) VNFNFNGL Tetramer (1:100, NIH Tetramer Core Facility ... AB_493696), 0.5 μL of MHC II eFluor 450 (clone M5/115.15.2, ...

We aimed to restore MHC-I expression on the surface of solid tumors including breast cancer and melanoma cells to regain sensitivity to immunotherapy and suppress metastatic progression. We screened a ...

MHC-Peptide Tetramers play a crucial role in immunological research, particularly in cancer immunotherapy, vaccine development, and infectious disease studies. LOS ANGELES, CA, UNITED STATES ...

Golden, CO, Feb. 24, 2025 (GLOBE NEWSWIRE) -- Ignite Proteomics LLC, a subsidiary of IMAC Holdings, Inc. (Nasdaq: BACK), today announced the presentation of new data demonstrating that MHC-II ...

HLA class I antibodies were identifiable by the microcytotoxicity assay, but HLA class II antibodies often remained unidentified due to the overlapping distribution of MHC class I and II antigens.

We infected Nur77 mice with lymphocytic choriomeningitis virus (LCMV-Armstrong) to generate a robust memory compartment, where quiescent LCMV-specific memory CD8 + T cells could be readily tracked ...

Furthermore, examining 3D structures of T cell receptors binding to fragments carried by MHCs helps to identify how changes in the sequence of the MHC can influence which receptor will be able to ...

The immune system protects against disease by recognizing invading pathogens, such as bacteria and viruses, and launching various responses to eliminate them. In vertebrates, such as mice and humans, ...