Whilst the ultimate outcome of the lytic cycle is production of new phage progeny and death of the host bacterial cell, this is a multistep process involving precise coordination of gene transcription ...

We selected KSHV ORF68 as our model gene, as it is required for progeny virion production, has no known direct transcriptional regulators, and its expression initiates early in the lytic cycle and ...

Studies suggest over 50% of latent EBV may be refractory, resisting entering the cell lytic cycle. The mechanism underlying this process remains unclear but it seems closely associated with high ...

Phage infection occurs via two alternate cycles, initiated by the injection of phage DNA or RNA into the host. In the lytic cycle, this is translated to produce phage proteins that hijack the host ...

The lytic and lysogenic cycles are the two main phases of a virus’ infective lifecycle and route to replication. The lytic cycle, or virulent infection, involves a virus taking control of a host cell ...

Our finding reveals that SOX acts as a unique viral inhibitor of AIM2 to evade the inflammasome activation during KSHV lytic cycle. Inflammasomes are one kind of important innate immune defense ...

Dysregulation of this network highlights a novel mechanism of cell cycle control during KSHV lytic replication in B cells. Importantly, disruption at any point within this novel ncRNA regulatory ...

Depletion of MYC or factors important for MYC expression reactivated the lytic cycle, including in Burkitt xenografts. MYC bound the EBV genome origin of lytic replication and suppressed its looping ...

Viruses that replicate using only the lytic cycle are known as virulent bacteriophages, and viruses that replicate using both lysogenic and lytic cycles are known as temperate bacteriophages.