Northwestern Medicine scientists have developed a promising approach to killing treatment-resistant cancer cells by ...

Discover how biotechs and big pharma are developing novel treatments for high cholesterol with a range of different targets.

Horton, and David L. Silver. The regulation of lipoprotein lipase (LPL)–mediated processing of triglyceride-rich lipoproteins (TRLs) by angiopoietin-like (ANGPTL) proteins functions to partition the ...

Lipoprotein lipase releases the fatty acids from triglycerides ... isoform with a large number of kringle repeats. The metabolism and function of Lp(a) is not well understood.

Since high amylase levels may be associated with decreased kidney function ... Abnormal levels of lipase may also exist in people with familial lipoprotein lipase deficiency.

Lipoprotein lipase (LPL) plays a crucial role in preventing dyslipidemia ... In many instances, HTG is not caused by LPL variants leading to compromised LPL protein structure and function, but by a ...

Gaudet noted that loss-of-function mutations in and pharmacologic ... ANGPTL8 forms a complex with ANGPTL3 that inhibits lipoprotein lipase 100-fold more potently than ANGPTL3 alone, and ...

Among the identified DEPs, lipoprotein lipase (LPL) was upregulated in sexually mature chicken ... studies to elucidate the mechanism of lipid metabolism to regulate the function of avian GCs during ...

Loss-of-function mutations in ANGPTL3 are associated ... of plasma lipoprotein levels by inhibiting the enzyme lipoprotein lipase. Here, I review the role of ANGPTL3 in lipoprotein metabolism.