Endogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for ...

Cells change their metabolic profiles in response to underlying gene regulatory networks, but how can alterations in metabolism encode specific transcriptional instructions? Here, we show that forcing ...

PPARα activators induce fatty acid oxidation in the liver, thereby improving lipid and carbohydrate metabolism in obese mice. In this study, the dietary cis-carotenoids bixin and norbixin, which are ...

Second, by recruitment of intestinal lymphatic drug transport (and reduced first-pass metabolism ... long-chain and unsaturated lipids) recruit endogenous and exogenous lipid transport and ...

These findings indicate that exogenous lipid supplementation alone is not sufficient to rescue lipid metabolism, suggesting that these mice rely on glucose metabolism as an alternative fuel source.

Potential topics include, but are not limited to: •Biological function in the new compounds releasing H 2 S, polysulfide and SO 2 •New methods for detection of endogenous and exogenous H 2 S •Advances ...

In support of this hypothesis, several recent studies have shown that reduction of toxic lipids is associated with improved metabolism and function of the heart. The role of the metabolic syndrome was ...

To study isoprenoid and lipid metabolism in grape skin chloroplasts, metabolites of enriched organelle fractions were analyzed by high-performance liquid chromatography-high-resolution mass ...

We plan to undertake a systematic review to synthesise the evidence on the association between endogenous and exogenous maternal sex hormones and the risk of asthma and allergy in the offspring.