Mapping an antibody’s epitope, where it binds a target, can now be done in three dimensions, which optimizes the selection of application-specific antibodies.

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

Proteins change their conformations as part of their biological functions, for example, when binding another molecule (ligand). Two pathways are conceivable: Either the ligand binds preferentially to ...

The best 4K Blu-ray players deliver the ultimate picture quality for watching movies and TV series at home. Although streaming services are popular, Blu-rays deliver video at a higher bitrate ...

Abstract: Predicting protein-ligand binding affinities is a critical problem in drug discovery and design. A majority of existing methods fail to accurately characterize and exploit the geometrically ...

These medications help by increasing acetylcholine levels. Memantine works by preventing glutamate from attaching to the N-methyl-D-aspartate (NMDA) receptor (binding site). Glutamate is a naturally ...

In this way, the small-molecule-binding proteins can be treated like ... spectrum of ligands (molecules that bind to protein receptors to send signals between cells), including cholic acid ...

Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, 2318 Yuhangtang Road, Hangzhou 311121, PR China Department of Chemistry, and the ...

Get Instant Summarized Text (Gist) Researchers have discovered that heat causes the TRPV1 receptor, a protein involved in detecting temperature and pain, to partially unfold, leading to its activation ...

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, P.R. China Bioinspired Engineering ...