Cysteinyl leukotrienes (CysLTs) are potent bronchoconstrictors, playing pivotal roles in inflammatory diseases. These lipid mediators exert their effects by activating two G protein-coupled receptors, ...

Ligand Pharmaceuticals (LGND) and Channel Therapeutics (CHRO) announced the signing of a definitive merger agreement to combine Ligand’s wholly ...

Stifel initiated coverage of Ligand (LGND) with a Buy rating and $143 price target Ligand, which provides “an important source of ...

5 By contrast, combinatorial bsAbs can interact with each of their targets independently, without the need for concurrent binding. This category includes compounds targeting receptor tyrosine kinases ...

Nuclear receptors form a family of proteins capable of accommodating a wide variety of small molecules in their ligand binding domain, ranging from therapeutic compounds to endocrine-disrupting ...

A new study published in Nature presents compelling evidence that H5N1 viruses from bovine sources maintain a preferential binding to avian-type sialic acid receptors while demonstrating limited ...

New research published in PNAS investigates the potential of H5Nx viruses to adapt to human hosts by altering their receptor-binding properties, with a focus on the implications of the Q226L mutation ...

Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard-Karls-Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany Tübingen Center for ...

These obstacles can be categorized into receptor-, ligand-, carrier-, and clinical translation-specific concerns, each of which requires creative strategies and further technical progress [226–228].

mwSuMD simulation of PF06882961 binding to GLP-1R and receptor activation. Each panel reports the root mean square deviation (RMSD) to a GLP-1R structural element or the position of the ligand in the ...