Lentiviral transduction is a popular delivery platform for applications such as CAR-T cell engineering or CRISPR-Cas9 gene editing, as it can transduce both dividing and non-dividing cells and ...

MxV-G is a novel fusogen for lentiviral packaging that achieves higher vector titers and enhanced transduction efficiency. The detargeted MxV-G mutant abolishes native receptor binding while ...

Compared with the traditional VSV-G pseudotyped lentiviral vector, MxV-G pseudotyped vector not only enhances viral titer and transduction efficiency but also enables generated CAR-T cells to more ...

Get Instant Summarized Text (Gist) Generative AI has been used to design synthetic DNA regulatory sequences that precisely control gene expression in healthy mammalian cells. These AI-generated ...

"LICONN brings us a step closer to assembling the puzzle pieces of the mammalian brain and better understanding its functioning both in health and disease," Danzl concludes.

Lentiviral vectors (LVVs) have proven to be extremely versatile genetic delivery vehicles, gaining space as a gene transfer technology tool used both for cell and gene therapies. They are utilised ...

A genome-wide lentiviral sgRNA library assessed growth dependencies of KRAS and NRAS mutant lines under controlled conditions. Mutant- and isoform-selective dependencies were then confirmed using ...

AGC Biologics will provide lentiviral vector (LVV) material using its proprietary ProntoLVV™ platform to prepare these therapies for CTA / IND submissions. Quell is working to create ...

Greater numbers of circulating stem cells increase the efficacy of in vivo gene therapy techniques, potentially reducing the price tag of lifesaving treatments.