Healthy cells are constantly breaking down proteins and building up new ones with the help of enzymes aptly named unfoldases, because they unravel proteins tagged for destruction or recycling. Now, a ...

However, the precise mechanisms by which lens proteins both prevent aggregation and maintain lens transparency are largely unknown. Lanosterol is an amphipathic molecule enriched in the lens.

New research reveals how proteins that are critical for the transparency of the eye lens are properly sorted and localized in membrane bilayers. The study analyzes how interactions between lipid ...

The mechanism behind how proteins that are critical for the transparency of the eye lens are properly sorted and localized in membrane bilayers has been highlighted in new research.

α-Crystallin is a major lens protein, comprising up to 40% of total lens proteins, where its structural function is to assist in maintaining the proper refractive index in the lens. In addition ...

Scientists have associated many neurodegenerative disorders including Alzheimer’s, Parkinson’s, Huntington’s, and prion diseases with protein misfolding and aggregation, where incorrectly folded ...

In Alzheimer's, Parkinson's, and type 2 diabetes, harmful protein aggregates and deposits, known as amyloid plaques, develop. There is also much evidence that these three diseases are ...

See ocumetrics bionic lens from a couple months back, but as far as I can tell, the procedure & replacement lens sounds identical to existing cataract surgery. pmshah July 24, 2015 01:33 AM ...

By studying protein accumulation in the nematode worm C. elegans Dr Della David and her team found that even when the typical protein quality control mechanisms were disrupted, there were lower levels ...

Aggregation of TDP-43 in the cytoplasm is caused by another protein aggregating in the nucleus, a cytoplasm-based protein called charged multivesicular body protein 7 (CHMP7). Too much CHMP7 in the ...

Purdue University researchers have taken the first steps to treat Alzheimer’s disease, Parkinson’s disease and Type 2 diabetes by creating multiple patent-pending compounds shown to inhibit protein ...