Molecular chaperones and small molecule chaperones or chemical chaperones like osmolytes, hydrophobic molecules and pharmacological chaperones are known to prevent protein misfolding by preventing ...

Therapeutic protein and peptides’ half-life can be improved by using the FcRn approach because of its high expression in various ocular tissues like lens epithelium, conjunctiva lymphatic vessel, ...

A general phenomenological kinetic model of irreversible protein aggregation in aqueous solution proceeding via non-native conformations is examined with a view toward the development of techniques to ...

Rao PV, Huang QL, Horwitz J, Zigler SJ . Evidence that alpha-crystallin prevents non-specific protein aggregation in the intact eye lens. Biochim Biophys Acta 1995; 1245:439–47. Article Google ...

Concretely, we introduce a deformable aggregation module, which integrates feature alignment and feature aggregation in an ensemble, to reduce inter-modality misalignment and make full use of ...

A new large-scale study has mapped the first molecular events that drive the formation of harmful amyloid protein aggregates found in Alzheimer's disease, pointing towards a new potential ...

A new large-scale study has mapped the first molecular events that drive the formation of harmful amyloid protein aggregates found in Alzheimer's disease, pointing toward a new potential ...

Secondly, by combining mutations, we can systematically probe the interactions between different parts of the protein as the aggregation reaction initiates. “This is crucial to understand the first ...