This paper presents the important finding that BNIP3/NIX, a mitophagy receptor, and its binding to ATG18 are required for mitophagy during muscle cell reorganization in Drosophila. Although the ...

While autophagy is relevant to many biological processes and often serves as a gatekeeper of homeostasis, when something goes wrong it can either lead to disease or be activated to fight against it.

Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China ...

New research from the Regulatory RNA and Chromatin lab at the Josep Carreras Institute sheds light on one of these alterations: autophagy malfunction. The inner life of a cell is highly dynamic ...

Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, Bengbu, Anhui 233030, China Clinical Testing and Diagnose Experimental Center, ...

Under nutrient deprivation, AMPK activates autophagy, yet mTOR inhibition is relieved. Subsequent activation of ULK1 and BECN1 complexes promotes formation of phagophore. ATG5-12-16L complex and ATG8 ...

Here, we propose a simple two-step model to understand changes in autophagosome formation and degradation using data from conventional LC3-II Western blot, and test it using two models of autophagy ...

One of the key characteristics of Bluetooth LE Audio is the new high performing standards-based LC3 audio codec. LE Audio requires the LC3 codec which supports scaling from 345kbps to just 16kbps ...

This analysis also revealed that a particular autophagy receptor, TAX1BP1, mediates clearance of ubiquitylated Mtb and targets bacteria to LC3-positive phagophores. These studies provide a new ...