Explore the science behind cold plunges and how they transform your cells for better health and cold tolerance.

This study, though small (just 10 young men), suggests that cold exposure can activate molecular pathways associated with ...

Cold plunges have become a fixture on wellness feeds and gym schedules. But what does science say when you strip away the ...

In this study, we also found that overexpression of SIRT1 could inhibit the expression of autophagy marker p62 and promote the expression of LC3-II/I and Beclin1, while the addition of 3-MA partially ...

In the siRNA knockdown group, synuclein and LC3 showed normal anterograde axoplasmic transport, while retrograde axonal transport was blocked. The changes in intracellular autophagy flow, that is, the ...

Notably, a large number of vesicles with double-membrane structure indicating autophagosome were found to surround the aberrant spermatozoa, suggesting the activation of autophagy. Several proteins, ...

Results Rapamycin affected the mTOR signalling pathway in mouse knee joints as indicated by the inhibition of ribosomal protein S6 phosphorylation, a target of mTOR and activation of LC3, a main ...

After autophagy was blocked, the therapeutic effect of BSP was ... 34 (VPS34), matrix metalloproteinase 9 (MMP9), microtubule-associated protein light chain 3 (LC3) antibody, HRP goat anti-mouse ...