The kinesin motor domain is composed of a single globular catalytic core and a short strand 'neck linker'. The catalytic core contains both the ATPase reaction centre and the microtubule binding ...

The antimitotic properties of parthenolide, a natural compound with known anticancer activity, have been largely ...

Here we show that the growth of microtubules induced in fibroblasts by removal of the microtubule destabilizer nocodazole activates Rac1 GTPase, leading to the polymerization of actin in ...

The centrosome is the main microtubule‐organizing centre. It also organizes a local network of actin filaments. However, the precise function of the actin network at the centrosome is not well ...

§ Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei 100, Taiwan ∥ Genome and Systems Biology Degree Program, National Taiwan University and ...

This study presents a valuable finding that MK2 inhibitor CMPD1 can inhibit the growth, migration, and invasion of breast cancer cells both in vitro and in vivo by inducing microtubule ...