This study provides compelling evidence that kinesin's stepping mechanism is governed by strain-induced conformational changes in its nucleotide-binding pockets. Using pre-steady state kinetics and ...

With this strategy, Hell’s team fluorescently tagged and tracked a motor protein called kinesin as it performed its signature walk down the length of a microtubule. Kinesin is a vital player in ...

The researchers enclosed the microtubule-kinesin-ATP mixture in a droplet of oil. A video of the reaction showed two microtubules aligned parallel to each other. A kinesin molecule then came between ...

that is directed to microtubule plus ends, and a carboxy-terminal kinesin motor, Ncd, that is directed towards microtubule minus ends. This activity maintains the spacing between separated ...

In recent years, similar phenomena have been observed with active micro-units such as bacteria, chemically-activated motile colloids, even microtubule–kinesin bundles (active nematics) Active matter ...

My current projects address motor protein dynamics and microtubule length regulation, cytoskeletal active matter, mitotic spindle assembly and regulation, chromosome segregation in cell division, and ...