Because kinesin-1 motors processively move along individual protofilaments ... This mapping allows the correlation of motor-filament interactions with the microtubule fine-structure. With the ...

The discovery of kinesin proteins associated ... destabilizing the microtubule structure. Consistent with this hypothesis, we characterized an interaction between SIAH-1 and the C-terminal half ...

elegans kinesin-2 motor protein OSM-3 ... (C) Phosphorylated 488-490 residues are at the “elbow” of OSM-3. It shows the overall structure of the homodimeric OSM-3 predicted by alphafold2. The dashed ...

Additionally, we expect to nominate a development candidate for our novel Kinesin program by mid-year, with plans to submit an IND in the first half of 2026." Enrollment is ongoing in the Phase 1/ ...

A unique feature of HR is that it repairs the damage to the DNA in a highly accurate way. In eukaryotic cells (those with a ...

For hundreds of years, Andean people recorded information by tying knots into long cords. Will we ever be able to read them?

This landmark study describes the structure of the human RAD51 filament with a recombination intermediate called the displacement loop (D-loop). Using cryogenic structural, biochemical, and ...

provide mechanistic insight into the recruitment and maintenance of kinesin-12 POK2 ... When working in teams, these motors achieve forces of 1 pN or more, enhancing MT-sliding velocities ...

Researchers have identified a never-before-seen mechanism that enables HIV-1 to evade the body's natural defenses and use it ...

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"We're using the structure-based information that we've gained here to guide us in improving molecules that we hope will ...

UNIVERSITY PARK, Pa. — Penn State University Libraries presented its eighth annual Undergraduate Research Award: Excellence ...