Researchers have developed a vascularized organoid model of hormone secreting cells in the pancreas. The advance promises to improve diabetes research and cell-based therapies.

Researchers led by Maike Sander, Scientific Director of the Max Delbrück Center, have developed a vascularized organoid model of hormone secreting cells in the pancreas.

Our aim was to investigate whether epithelial cell defects could originate from changes in the epithelial compartment imprinted by the disease. Design Epithelial organoid cultures (EpOCs) were ...

Objective Reduced Paneth cell (PC) numbers are observed in inflammatory bowel diseases and impaired PC function contributes to the ileal pathogenesis of Crohn’s disease (CD). PCs reside in proximity ...

Stem cell therapy is an emerging treatment for type 2 diabetes. Although it’s not yet FDA-approved in the United States, it is a rapidly expanding and promising field of research. Stem cells are ...

In this study, we investigated the impairments of UC to small intestine and further explored how iron metabolism regulated epithelial integrity and the activity of intestinal stem cells (ISCs ...

Metabolomic, transcriptomic, and scRNA-analyses revealed that EGFR deletion in KRAS-mutant organoids reduced their phenotypic heterogeneity and activated a distinct cancer-stem-cell/WNT signature ...

Serotonergic enterochromaffin (EC) cells are sensory cells within the gut that detect noxious stimuli and transduce this information to sensory nerve fibers to elicit defensive responses such as ...