Gut organoids are three-dimensional (3D), stem cell-derived structures that mimic the cellular composition and functions of the human gastrointestinal (GI) tract. By replicating digestive ...

In this study, we investigated the impairments of UC to small intestine and further explored how iron metabolism regulated epithelial integrity and the activity of intestinal stem cells (ISCs ...

Our aim was to investigate whether epithelial cell defects could originate from changes in the epithelial compartment imprinted by the disease. Design Epithelial organoid cultures (EpOCs) were ...

The pancreatic duct plays a key role in collecting pancreatic juice, which is rich in digestive enzymes ... These pancreatic organoids expressed the stem cell marker LGR5 mRNA and the ductal marker ...

Model more closely replicates natural environment of the pancreas, which will be essential for studying diabetes and ...

Researchers have developed a vascularized organoid model of hormone secreting cells in the pancreas. The advance promises to improve diabetes research and cell-based therapies.

Researchers led by Maike Sander, scientific director of the Max Delbrück Center, have developed a vascularized organoid model ...

The aging of the innermost cell layer of blood vessels leads to cardiovascular diseases. Researchers at UZH have now shown ...

Bats are known as natural hosts for highly pathogenic viruses such as MERS- and SARS-related coronaviruses, as well as the ...