Researchers have developed a vascularized organoid model of hormone secreting cells in the pancreas. The advance promises to improve diabetes research and cell-based therapies.

Researchers led by Maike Sander, Scientific Director of the Max Delbrück Center, have developed a vascularized organoid model of hormone secreting cells in the pancreas.

Drug-induced liver injury (DILI) is a frequent cause of acute liver failure and drug withdrawals. Liver organoids, as a ...

Blood and intestinal samples were collected longitudinally and analysed using CyTOF and scRNA-seq. Stem cell autografts were functionally assayed in mouse xenograft models. Results scRNA-seq and CyTOF ...

Serotonergic enterochromaffin (EC) cells are sensory cells within the gut that detect noxious stimuli and transduce this information to sensory nerve fibers to elicit defensive responses such as ...

These pancreatic organoids expressed the stem cell marker LGR5 mRNA and the ductal marker protein ... Nuclear staining was done using DAPI (Nacalai Tesque). For organoid immunostaining, organoids were ...

Our cardiac organoid can save a lot of time and money." "We differentiate induced pluripotent stem cells into cardiac muscle cells, fibroblasts and endothelial cells. Then we mix them with ...

The intestinal barrier is in close contact with gut microbiota on its luminal side and with enteric neurons and glial cells on its tissue side. Mounting evidence now suggests that the intestinal ...