The authors have declared no conflicts of interest. Leydig cell tumours (LCT) are rare sex-cord gonadal tumours that account for less than 5% of testicular neoplasms. They are often discovered ...

1 Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States 2 Department of Urology, Beth Israel Deaconess Medical Center and Harvard Medical ...

This important study reports single-nucleus multiomics-based profiling of transcriptome and chromatin accessibility of mouse XX and XY primordial germ cells (PGCs). The main conclusions of this study, ...

Cancer immunotherapy is shifting paradigms in cancer care. T cells are an indispensable component of an effective antitumor immunity and durable clinical responses. However, the complexity of the ...

Spermatogenesis, the complex process of male germ cell proliferation, differentiation, and maturation, is the basis of male fertility. In the seminiferous tubules of the testes, spermatozoa are ...