The interaction of Mia40 with Erv1/ALR is central to the oxidative protein folding in the intermembrane space of mitochondria (IMS) as Erv1/ALR oxidizes reduced Mia40 to restore its functional state.

A dysfunction in complex I can result in higher cellular levels of NADH, which in turn strengthens the interaction between apoptosis-inducing factor 1 (AIFM1) and Mitochondrial intermembrane space ...

Mitochondria are responsible for producing and providing energy to our bodies, especially in organs such as the heart, brain, and muscles, which require high-energy production. These organs ...

ATP synthase is located in the inner membrane of the mitochondria. Once synthesized, ATP is stored inside the mitochondrial matrix or it can be transported into the intermembrane space of the ...

GSNOR, which is localized in the matrix or intermembrane of mitochondria is reduced in failing cardiomyocytes. Mitochondrial GSNOR denitrosylates ANT1 (adenine nucleotide translocase 1) at cysteine ...

Mitochondria contribute to this redox stress by generating reactive oxygen species (ROS) along the electron transport chain (ETC), which are released to the matrix and the intermembrane space (IMS).

These mice are viable and we have found no adverse cardiac or metabolic phenotypes. We find that EFHD1 is expressed in the intermembrane space of the mitochondria and associates strongly with ...

This fundamental work advances our understanding of the functional role of connexin43 in mitochondrial. The evidence support that it forms hemichannels at the mitochondrial inner membrane, and serves ...

The three are 1) activation of the small GTPase protein Rac1 and its localization into the intermembrane space of mitochondria in the BAL cells, 2) increased production of mitochondrial reactive ...

This Perspective aims to address recent work that has expanded our understanding of how bacteria achieve intermembrane transport. While we address recent work on major systems of lipid and hydrophobic ...