3–6 Mice that are deficient in either interleukin-10 or interleukin-10 receptor 2 have been shown to have severe enterocolitis, 26–28 a finding that underscores the pivotal role of interleukin ...

Interleukin (IL)-10 is an important immunoregulatory cytokine that mediates its effects via a transmembrane receptor complex consisting of two different chains, IL-10R1 and IL-10R2. While IL-10R2 ...

Summary: Tocilizumab is a novel monoclonal antibody that competitively inhibits the binding of interleukin-6 (IL-6) to its receptor (IL-6R). Inhibiting the entire receptor complex prevents IL-6 ...

R denotes receptor. Interleukin-23 can expand a population ... which resemble regulatory T cells and produce interleukin-10 and interferon-γ. The interaction with Tr1 cells may allow interleukin ...

9,10 The history of this soluble interleukin-2 receptor, also known as sIL-2R, sCD25, sTAC, sIL2R, or IL-2RA, dates back to 1985 when it was initially described as actively released by activated ...

Five other patients with DLBCL had lymphoma that had relapsed 10 months or less after ASCT as their last treatment ... Fig 2. Chimeric antigen receptor (CAR) targeting CD19 (CAR-19) T cells eradicated ...

with efficacy depending on the high expression of interleukin-10 receptor (IL-10R) on CD8 + TRM cells. To investigate the molecular mechanisms underlying the high expression of IL-10R on CD8 + TRM ...

Cytokine release syndrome was observed in six of eight (75%, grade 1 in all but one patient) and associated with increased circulating IL-6 and IP-10 (P < .05 ... CART, chimeric antigen receptor; DL, ...