Every living creature on Earth needs to protect itself from things that would do it harm. Bacteria are no different. And ...

Sterols, such as cholesterol in our bodies or ergosterol in yeast cells, are among the most abundant lipids in eukaryotic ...

The complexes sit in the inner mitochondrial membrane, where they interact ... of mutations on the lipid-facing surfaces of Complex I proteins — parts not involved in protein-protein interactions.

Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai 201804, China Department of Gynaecology and Obstetrics, Shanghai Key Laboratory of ...

To gain a comprehensive understanding of the effects of RTN4IP1 depletion on respiratory chain complex assembly and the steady-state levels of other mitochondrial proteins, we employed complexome ...

Mitochondria are membrane-bound cell organelles that undertake the majority ... and −503 improves muscle protein synthesis mitochondrial density and enhances ATP production (Long et al., 2023). Within ...

Emerging evidence suggests that pathological mechanisms relating to protein folding and mitochondrial dysfunction are significant factors in the disease onset of different types of open-angle glaucoma ...

Some of the proteins are made in the cell’s cytoplasm and some inside the mitochondria. They find their way to the mitochondrial inner membrane to form the complex. To study RC1, the scientists ...

Human complex II deficiency resulting from mutations in the structural subunit genes can lead to metabolic disease or cancer. Here, we have determined the structure of this complex which explains how ...

Structural studies of membrane proteins historically have relied almost exclusively on first removing membrane proteins from the membrane with dispersive agents like detergents. But dispersive agents ...