Accumulation of fat molecules is detrimental to the cell. Researchers from the Yong Loo Lin School of Medicine, National ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs). Here, using a ...

Researchers from the University of Bergen, for the first time, show how mitochondria act as “reservoirs” to hold NAD, which plays an important role in creating energy in the body. Scientists ...

They found that the formation of SC-XL increases the number of folds in the inner mitochondrial membrane, expanding its surface area. As a result, more energy-producing proteins can be embedded in ...

Elamipretide is a cell-permeable peptide compound designed to improve mitochondrial function by targeting the inner mitochondrial membrane where it binds reversibly to cardiolipin. We continue to work ...

The new Prescription Drug User Fee Act target date is April 29, 2025. The Food and Drug Administration (FDA) has extended the review period for the New Drug Application (NDA) for elamipretide for ...

The pleura (plural: pleurae) is a two-layered membrane that covers the lung. Between the layers is a small amount of lubricating fluid, known as pleural fluid, which helps cushion the lung and reduce ...

Plans by P&N Sleiman Group to expand a trio of towers in Sydney’s inner west have been greenlit. The developer, led by managing director Pierre Sleiman and head of construction Nabil Sleiman, ...

Biologists had long believed that bringing order and organization to the chaos of molecules inside a cell depended on membrane-bound compartments called organelles, such as the mitochondria.