In an article published in the journal Trends in Biochemical Sciences, Alicia Kowaltowski, full professor at the University ...

A paper by scientists affiliated with the University of São Paulo highlights new discoveries regarding the mechanisms of oxidative phosphorylation involved in ATP production. Recent studies have ...

In an article published in the journal Trends in Biochemical Sciences, Alicia Kowaltowski , full professor at the University of São Paulo's ...

Two import pathways that direct proteins into the mitochondrial inner membrane and matrix have been known for many years. The identification of numerous new transport components in recent ...

Mitochondria are organelles with two well-defined compartments: the matrix, surrounded by the inner membrane (IM), and the intermembrane space, surrounded by the outer membrane (OM). The IM is ...

They found that the formation of SC-XL increases the number of folds in the inner mitochondrial membrane, expanding its surface area. As a result, more energy-producing proteins can be embedded in ...

Five major protein import pathways have been identified so far: (1) Presequence-carrying preproteins are imported through the translocase of the outer mitochondrial membrane (TOM) and the translocase ...

The FDA has extended the review period for the New Drug Application for elamipretide for the treatment of Barth syndrome.

2003). FNQs, isolated from the inner bark of tropical trees, were shown to target VDAC1 (Simamura et al., 2006). FNQs might induce apoptosis via the NADH-dependent production of ROS, leading to ...

Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs). Here, using a ...