Muscimol, a GABA-A (GABAA) receptor agonist, enhances GABA's inhibitory effect on neuronal activity by activating GABAA ...

Drug-induced liver injury (DILI) is a frequent cause of acute liver failure and drug withdrawals. Liver organoids, as a ...

By promoting liver progenitor cell expansion through a specific signaling pathway, this method offers a promising route to improve organoid models and regenerative medicine. Organoids are small ...

The increasing implication of glial cells in neurodegenerative diseases makes them an appealing addition to iPSC-based model systems for investigating ... neurons and complex 3D organoid cultures with ...

Organoids are three-dimensional (3D) cell culture systems that can be called “mini-organs” as they mimic some of the key multicellular, anatomical and even functional characteristics of real organs.

“If we analyze the cerebrospinal fluid, we find that the protein composition is actually closer to what you see in a developing brain than what you would see in other organoid stocks which ... stem ...

To create a large biobank, reliable culture and analysis methods are required, including robust quality-control assays to evaluate the key characteristics of the organoid disease model created.

is entering into compound screenings and enhancing our iPSC organoid disease modeling in the discovery stage. Our cutting-edge application of AI technologies and Vyant Bio’s own analytics for ...

While not exact replicas of human organs, they offer significant insights. Scientists now present a new organoid model that reveals details of the developing nervous system's response to viral ...

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More information: Yoshiki Kuse et al, Placenta-derived factors contribute to human iPSC-liver organoid growth, Nature Communications (2025). DOI: 10.1038/s41467-025-57551-w ...