Upon GTP binding and hydrolysis, auto-inhibited GBP1 monomers dimerize and ... Our results reveal a sophisticated activation mechanism for GBP1, in which nucleotide-dependent structural changes ...

The mechanism for GTP hydrolysis in the free heterodimer, however, is not understood. Additionally, there has been debate concerning whether the GTP-state lattice is expanded or compacted relative to ...

The mechanism of cellulase-catalyzed cellulose hydrolysis, design of cellulase-mimetic catalysts, and the issues related to these cellulase-mimetic catalysts are critically discussed. Some potential ...

1c00836. Kinetic measurements including rates of hydrolysis under various pH and buffer conditions, dependencies of rate constants upon temperature, solvent isotope effects and proton inventory, and ...

Scientists are increasingly recognizing escapement mechanisms as fundamental to all cellular processes driven by hydrolysis of fuel molecules like ATP and GTP. Carter's work shows for the first ...

Adenosine triphosphate (ATP) is a key molecule which upon hydrolysis provides energy to facilitate a variety of cellular processes that are essential for life. The cell utilizes the energy of ATP ...

Chemical Species involved in the inhibition reaction of GSTP1. As far as the proton affinity calculations for establishing the oxygen carbonyl to be considered in the hydrolysis mechanism at acidic ...

The mechanism is illustrated in Figure 2. The reverse of imine formation is called imine hydrolysis, yielding the corresponding amine and carbonyl containing compound (aldehyde or ketone).

We have now uncovered a novel mechanism by which LIPA controls macrophage inflammatory response by limiting continued clearance of apoptotic cells. Notably, our mechanistic studies demonstrated that ...

Experimental details and additional data. This material is available free of charge via the Internet at http://pubs.acs.org.