7 To evaluate transgene delivery efficiency, 185-day-old retinal organoids were loaded with AAV2-WT and three different serotypes: IVT-9, IVT-18 and IVT-21. For each organoid, 1 x 1010 vg of each ...

Researchers have identified novel retinal vascular signatures that are significantly associated with the risk for a first stroke. When combined with age and sex, these retinal “fingerprints ...

An innovative organoid model mirrors the pancreas' complexity, generating all three key cell types to explore development and possible regeneration. Laura is an assistant editor for The Scientist. She ...

Newcells’ iPSC-derived retinal organoids offer a unique in vitro platform for disease modeling and investigating drug efficacy. These retinal organoids are fully stratified and present all of the ...

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A corneal abrasion is a scratch on your eye. It can happen in an instant — such as when you poke your eye or something (like dirt or sand) gets trapped under your eyelid. Your eye hurts, and ...

When it comes to addressing uneven skin texture and tone, laxity and general glow – and creating beautiful skin – retinol is the gold standard. In fact, the best retinol serums and creams can be a ...

Investigative Ophthalmology & Visual Science (IOVS), published as ready online, is a peer-reviewed academic journal of the Association for Research in Vision and Ophthalmology (ARVO). IOVS ...

In this study, we have developed and characterized a novel human retinal organoid (RO) model derived from induced pluripotent stem cells (iPSCs) from patients with familial AD due to mutations in the ...

For instance, hepato-biliary-pancreatic organogenesis has been modeled using a multi-organoid fusion approach (Koike et al., 2019). In future studies, investigating the interaction between brain ...

This important study employed multiple orthogonal techniques and tissue samples to investigate the interaction between the NRL transcription factor and RNA-binding proteins in the retina. The findings ...

Pathological retinal neovascularization (RNV) is a major cause of blindness. Here, the authors show that endothelial protein C receptor (EPCR) promotes RNV through carbon monoxide derived from ...