Homologous recombination (HR ... perform supplemental functions in conjunction with the core proteins. The inability to properly repair complex DNA damage and resolve DNA replication stress ...

Figure 2: Scheme for the repair of a double-strand break by homologous recombination. We now have a detailed structure of the ssDNA-annealing domain of human RAD52 protein, and the way in which ...

The next steps in homologous recombination seemed blocked ... the heterochromatin domain in order to load Rad51 protein and complete the repair process. "There are a lot of moving parts here ...

where it prevents other proteins from further degrading the break site to repair by homologous recombination. "Double-strand breaks that are not protected by the RIF1 protein complex are ...

A protein with many jobs Although the ... previous surprising finding that XPG plays a role in homologous recombination -- a DNA repair process frequently used by cells to fix dangerous double ...

Researchers developed a biomimetic nanovesicle that crosses the blood-brain barrier, degrades DNA repair proteins, and ...

such as the processing of broken DNA for repair by homologous recombination. We are also interested in understanding the structural basis for the activation and catalytic modulation of helicase ...

Therefore, we previously developed the Repair Capacity (RECAP) test, a functional homologous recombination (HR ... such as loss of 53BP1 protein. Loss of 53BP1 was examined but not found in any ...

Common to these genomic integrity pathways is eventual repair by homologous recombination, a process that has been ... by cryo-electron microscopy are helping scientists learn how proteins and DNA ...

Current research has focused on the development of a companion diagnostic to identify sporadic BRCA-like tumors that would allow clinicians to identify those patients who may benefit from drugs ...

Homologous recombination plays essential roles in the ... In fact, many of the proteins involved in the sensing, signaling and repair of DSBs were identified through studies of inherited cancer ...