Genetic studies can offer powerful insights for the development of disease-modifying therapies for Alzheimer's disease.

HD (Huntington’s disease) WVE-003 is a first-in-class, allele-selective oligonucleotide for the treatment of Huntington’s disease (HD). In the SELECT-HD clinical trial, data demonstrated the ...

Objective Huntington disease (HD) is an autosomal dominant neurodegenerative disease involving motor disturbances, cognitive decline and psychiatric symptoms. Psychotic symptoms occur in a significant ...

At 24 months, additional benefits were observed, including dose-dependent trends on the Composite Unified Huntington’s Disease Rating Scale (cUHDRS) and other subscales, as well as a reduction in ...

BUFFALO, N.Y. — A decade ago, University at Buffalo researchers shed some light on an enduring neuroscience mystery: How exactly does a mutated huntingtin protein (HTT) cause Huntington’s disease?

If someone’s parent has Huntington’s, they have a 50% chance of inheriting the deadly disease. Conley says it’s like having Alzheimer’s, ALS and Parkinson’s all at once.

They found that two specific signaling proteins, GSK3ß and ERK1, were expressed more in the neurons of Huntington’s disease patients, so they prevented them from functioning in the neurons of ...

The number of people who have the gene that causes Huntington's disease in Northern Scotland has been accurately counted for the first time in 35 years in new research from the University of ...

A survey conducted in Canada examined the prevalence of perceived genetic discrimination against patients with Huntington disease. The respondents reported discrimination not only by insurance or ...

An approval decision for Stealth BioTherapeutics’ investigational treatment for an ultra-rare genetic disease has been delayed—again—this time, with no new decision date given. The biotech ...

A large trial showed that the weight-loss drug could reduce liver inflammation and scarring caused by a common condition. By Dani Blum I’ve reported on Ozempic since 2022. New research shows ...